CBGa & CBDa: Dynamic Duo for Bone Health & Beyond
Recently published medical research on bone health has uncovered yet another benefit of the combined synergistic actions of CBG and CBD. CBD has repeatedly revealed the ability to positively activate our ECS system, enabling it to address imbalances and deficiencies that come with age and disease. Studies continue to research the use of minimally processed CBD flowers (forms containing CBDa & CBGa) to battle viral load (infection) & proliferation (symptoms) of Covid 19. The newest scientific research on the combination of these same two cannabinoid’s shows exciting promise around bone loss & healing, immune response, MRSA, cancers, IBS/IBD, and neurological/mental health!
The presentation of CBG and CBD is expressed in two ways: first there are the acid forms CBGa and CBDa which are the precursors of CBD and CBG. The acid forms connect to enzymes rather than receptor sites. Secondly, there are CBG and CBD, the cannabinoids that result when CBGa & CBDa are transformed by the body’s own metabolism or by outside forces such as heat, botanical extraction methods and/or time. These plug directly into the CB1 and CB2 receptors with proven results.
Synergy Wellness products contain both acid and non-acid forms. Our products are created from raw flowers and thoughtfully processed to preserve the synergy that comes from retaining as much cannabinoidal variety as possible - this creates the ‘entourage effect’ where we believe therapeutic action is amplified.
Bone Health
A new study, published in 2023, details how CBD and CBG improve essential bone health by supporting strength (density) and healing. The study explores how these two compounds play a central role in bone formation and the regulation of bone cell growth. The ECS (endocannabinoid system) regulates and monitors both bone cell activity and bone remodeling. Endogenous cannabinoid ligands and receptors are seen in the regulation of bone mass and in the management of bone diseases, like osteoporosis. In study CBGa and CBDa were observed to increase the number of osteoblasts (cells that form bone tissue) per bone surface area, and which also induce the proliferation of bone lining cells. This promoted faster healing of fractures and increased bone density and strength in mice. Reduced pain during bone mending was also noted, this is significant in that NSAIDS (non-steroid anti-inflammatory drugs) can slow bone repair by inhibiting the inflammatory phase of the healing process. These findings suggest that age-related bone weakness, osteoporosis and brittle bone conditions can be ameliorated, and bone fractures can heal faster and more effectively using CBG and CBD.
Immune Support
Supporting our immune system is the reason we take vitamin supplements and now we know cannabinoids also play a part in boosting our immunity. The coronavirus pandemic led to important discoveries about the immune-supporting function of cannabinoids. In July 2020, researchers at the University of Lethbridge, Alberta, Canada published a paper on preventive treatments using CBD in the treatment of SARS Covid-19. Their research showed CBD could be used to combat Covid by modulating levels of ACE2 receptors: these receptors are found in vulnerable gateway tissue: lungs, kidney, liver, they act as entry portals for virus’ to gain access to cells - CBD blocked ACE2 receptor sites at a 70% percent success rate - radically reducing the possibility of infection.
In 2021 Oregon State University published results of tests using two cannabis compounds: CDGa - cannabigerolic acid and CBDa - cannabidiolic acid which were found to have potential to fight coronavirus. In laboratory tests these two compounds bound to the virus’ spike proteins and blocked a step that the pathogen uses to infect cells.
Brain Health
CBD and CBG play an overlapping role in brain health, using unique receptor pathways they produce a strong anti-inflammatory response to protect brain cells, reducing anxiety and overstimulation. Potential for treating Alzeimers and other neurodegenerative conditions comes as research in mice shows CBG exerting a complex action involving blocking 5HT1A , a serotonin receptor, while stimulating TRPV1 & 2 receptors which led to significantly enhanced learning and memory faculties. CBG and CBD act collaboratively and elicit bold responses, as an anti-anxiety medication the combination is recommended for panic attacks.
Appetite Stimulant and Microbiome Support
Often THC is an effective appetite stimulant but the psychoactive component can be difficult for some. Research shows positive results for CBG and CBD improving appetite and research with IBD sufferers has shown corresponding reduction in digestive pain and inflammation.
Anti-Tumor
CBD has been studied far greater than CBG and its anti-cancer properties are documented. Interest in CBG and its combined use with CBD has spiked with published research showing that CBG and CBD caused apoptosis (cell death) in colon cancer cells in mice.
The interest in CBD and CBG is reflected in ongoing research and the sphere of influence of these cannabinoids continues to grow.
New studies on the antibacterial properties of CBG and CBD showed positive results with methicillin-resistant MRSA staph infections.
In psychiatric medicine Dr Bonnie Goldstein is developing therapies for bi-polar conditions and autism which utilize CBG and CBD.
Following the science, Synergy Wellness offers doctor-formulated full spectrum CBDa/CBGa capsules which we recommend as a supplement to promote bone health, for mood & neurological applications, to address inflammatory conditions and provide support against viral infections including coronavirus and variants.
Super Immune Capsules: CBD & CBG w/ raw acids CBDa : CBGa | #241
● #241 - 30 capsules - $75 ON Sale! $60.00
● Ratio: CBD:CBDa : CBG:CBGa
Potency: 25mg per capsule ( CBD:CBDa : CBG:CBGa )
Total Cannabinoids: 750mg ( 25mg x 30 capsules)