Golden Nuggets from the Society of Cannabis Clinicians

by Ruth Hill RN BSN MAT CHPN

Anyone still wondering if cannabis is safe and medicinally effective must be living under a rock. Social media is now exploding with posts on the medicinal efficacy of cannabis. Physicians and nurses are recommending cannabis treatment. Medicinal cannabis organizations are expanding. To feel this excitement scroll the web pages of the Society of Cannabis Clinicians (SCC), and the American Cannabis Nurse Association (ACNA). Cannabis users are piercing through the propaganda bubble of the FDA. 

This article will expound on this excitement by reporting on the first conference of the SCC held at UCLA on September 2, 2023, cohosted by the Releaf Institute. Expert physicians presented cannabis as a first-line alternative treatment to unmanageable stubborn symptoms not responding to pharmaceuticals, the very definition of a refractory disease.  

Bonnie Goldstein MD, a pediatrician, kicked off the first lecture by describing the Endocannabinoid System (ECS). The ECS is a homeostatic regulatory system active throughout the brain and body, discovered in the 1990s by Rafael Mechoulam, an Israeli chemist.  The ECS is an adaptive response to cellular stress, it also maintains cellular homeostasis, fine-tunes synaptic transmission, and mediates synaptic plasticity. Most attendees had a basic knowledge of the ECS, but Dr. Goldstein took us on a deep dive into the chemistry and physiology of this newly discovered system. 

Dr. Genester Wilson-King lectured on Cannabis and Endometriosis. Wilson-King wasted no time in her condemnation of the overt bias of the medical industry toward Black women. This bias results in gross underdiagnosis of a malignant condition unresponsive to current treatment. Endometriosis has a 44% recurrence with medical treatment and a 55% recurrence with surgical treatment. Studies show cannabidiol (CBD) stops the migration of endometrial cells and resolves insomnia, nausea, pain, and dysmenorrhea.  

Dr. Patricia Frye presented the use of cannabinoids in the treatment of Autism Spectrum Disorder (ASD). The incidence of ASD is 2.76% of the U.S. population (9.6 million). In the year 2000, the incidence was 1:150. In 2020 the incidence exploded to 1:36. Researchers found children with ASD have low anandamide levels (endogenous THC). Dr. Frye used graphs to illustrate the extraordinary research on biomarkers developed by Goldstein for ASD.

Goldstein returned to the dais and revealed another U.S. patent on cannabis paid for by American taxpayers. The patent is on cannabidivarin (CBDV). It states that CBDV together with tetrahydrocannabivarin (THCV) far outperforms the use of pharmaceuticals for seizure disorders. The current practice of stacking one antiseizure drug after another induces side effects manifested by the child’s abhorrent behavior. After noticing a response, Goldstein’s treatment slowly tapers children off the multiple antiseizure drugs. There is NO research that verifies the efficacy of stacking antiseizure drugs. So, why do neurologists practice this?

Because trial and error use of pharmaceuticals often fails, how then do we palliate these women and children? Denying the use of cannabis as a first-line treatment is cruel and inhumane. This was emphasized over and over by our expert medical cannabis physicians. CBD has shown these drugs can be reduced by 56%. The research is there. Avoid sugar, lose weight, and focus on nutritional wellness instead of disease. 

We got our druthers twisted by Dr. Tim Fong who revealed how ineffective physicians are in diagnosing and managing Cannabis Use Disorder (CUD). If I knew someone with CUD, I would refer them to Dr Fong. He presented a long list of medications with dosages that I am sure many ER MDs are unfamiliar with. 

SCC Latin American Chapter led by Dr. Sandra Carrillo and Dr. Max Alzamora is spearheading some exciting projects to enhance the caliber of their cannabis programs.

The landscape of Latin America is rapidly advancing, and the SCC LATAM Chapter will be publishing cannabis science classes in Spanish. 

Most remarkable to me was Dr. Sherry Yafai’s palliative treatment of dementia. 5.8 million people in the United States have Alzheimer's disease and related dementias. Yafai presented four case studies where she recommended Nabilone, Dronabinol, or plant THC, CBD, and CBG-formulated products. All of her patients showed improvement in symptoms, one came out  of hospice care.

Variables affecting responses included age, cannabis product, and the length of time from initiation. It is imperative to focus on tapering down current pharmaceuticals with the corresponding titration up of cannabis. Research shows no efficacy with cannabis when the anti-seizure drugs were not simultaneously tapered down. This creates adverse events not related to cannabis, patience is required to successfully change drug protocols.  The best timeframe for revealing results is after four weeks. Presently in California, the family needs to administer cannabis medications in a medical institution.

A panel discussion of the obstacles patients experience, when their right to take a legal plant in a medical facility is prohibited. A typical Yafai treatment plan was: Average CBD: 120-127mg/week = 18 mg/day; Average THC: 52 - 55 mg/week = ~ 7-8 mg/day, a mix of inhaled and oral use was mentioned. The panel concluded that legalized cannabis is not enough, that there is an urgent need to implement the delivery of this miracle plant to everyone. Long-term use is prohibited when opioids are paid by the government with pennies on the dollar. We must combat the government’s War on Drugs propaganda. 

I’ve summarized the conference in this article but I do highly recommend the audio recording: listen to these outstanding physicians by clicking on this link and purchasing the webinar HERE.

Treating Covid -19 with CBDa:CBGa

By Billee Sharp

A few weeks ago I went down with my second Covid-19 infection.

Mercifully the symptoms, the sneezes, aching joints, loss of appetite and fatigue were not as severe as they were during my first infection with the Omicron variant a year ago.

The dominant variant in the U.S. currently is EG.5, a descendant of the Omicron variant. Omicron is no longer circulating and neither is the original Covid strain or the dangerous Alpha or Delta variants.

Nevertheless, EG.5 is a “variant of concern” according to the World Health Organisation. This is because EG.5 has a mutation which makes it significantly more contagious and potentially severe for vulnerable people.

I started taking Synergy’s Super Immune capsules after I had tested negative for the virus but while I was still experiencing symptoms, particularly fatigue and loss of appetite. I have been taking 50g daily and both my fatigue, which presented physically and cognitively and my lack of appetite began to recover immediately. I found that I could do more physically, even the massive basket of laundry! I also found my ability to concentrate on writing projects improved and my spirits lifted.

I’ve been doing a little research on the booster immunizations that are currently available as I have already had five doses of the vaccination since 2021 which seems like a lot!

So the current booster shot was developed to protect against the XBB.1.5 which is a closely related predecessor of EG.5. This indicates a good degree of protection as of the similar genetic coding of the sub variants of Omicron.

I’ve decided that I will continue to take the Super Immune capsules to prevent reinfection. The research shows the CBDa and CBGa block the spike protein of Covid virus’ and offer cellular protection from other RNA viruses like the common cold and influenza.

I’m very aware that my health relies on my immune system functioning and my ECS operating at full capacity. Taking CBDa and CBGa in full spectrum form has proved to be a huge support for my overall health.

Synergy Wellness has an ongoing sale on it’s Super Immune full spectrum capsules containing CBDa and CBGa, #241. Normally $75, these capsules are $60. We are extending the sale another month, till November 30th.

Full Disclosure on Full Spectrum Terpenes

Full Spectrum extraction is the most complete rendition of a plant's constituents, nothing is lost and nothing is added. Understandably this has many benefits for therapeutic use. Full spectrum cannabis extract contains all available cannabinoids and terpenes and both of these valuable compounds work with our endocannabinoid system (ECS) to promote healthy functionality through the body.

Understanding the role of terpenes in cannabis and the ways that they interact in the human body has been a topic of interest to medical researchers seeking to unravel the pathways of the ECS. We now know that terpenes can activate CB1 receptors just like cannabinoids, and that they are present in many other plants.

So terpenes are the hydrocarbon compounds responsible for aroma and flavor in a plant, for example pinene, is the dominant terpene present in pine trees and gives that distinctive pine smell and resin. Cannabis can contain many terpenes simultaneously but often there is one terpene that dominates.

Beta-Caryophyllene is a terpene that has been much researched in recent years. Taking a closer look at the studies on this terpene demonstrates the potential of terpenes to support health.

Beta-Caryophyllene (BCP) is one of the most frequently found terpenes in cannabis plants. It is characterized by its spicy and peppery flavor and is also present in a variety of other plants: black pepper, basil, oregano, cinnamon, hops, rosemary, cloves, citrus and leafy greens. Researchers have designated BCP as a “dietary cannabinoid” because it occurs in so many edible plants. Not surprisingly BCP is approved by the FDA for use as flavoring and fragrance.

Recent medical research studying BCP has found that the compound has value in treating non-alcoholic fatty liver disease, chronic pain and substance abuse. BCP is known to be a weak agonist at CB1 receptor sites and a strong agonist at the CB2 receptor site; ( “agonist” in this context means a substance that has a physiological impact at a receptor site.) The CB2 receptor plays an important role in immune function and inflammation. Research shows that BCP also interacts with PPARS

(peroxisome proliferator activated receptors) found on the surface of a cell's nucleus. CBD also activates PPARs which are regulators of energy levels and metabolism.

Researchers in Turin, Italy published their study on the effects of BCP on nonalcoholic fatty liver disease in the International Journal of Molecular Science in March, 2023. The research found that diseased liver cells improved and that this was achieved through the activation of CB2 receptors and two types of PPARs receptors.

A 2014 Chinese study from the Chongqing Medical School investigated neurological effects of BCP by studying a mouse model trial for Alzheimers. They found that CB2 activation and PPAR pathways as mediators of BCP prevented cognitive impairment. Further research into the neuroprotective properties of terpenes may lead to viable treatment for neurodegenerative conditions in humans.

A new Iranian study published in 2022 focussed on the anti-oxidant and immune modulating effects of BCP. The study showed the terpene reduced pro-inflammatory cytokines while increasing anti-inflammatory cytokines. Again CB2 and PPAR receptors were observed to be the main mechanisms of action.

Lastly, a Brazilian study in 2022 looked at BCP’s effect on animal models of addiction to cocaine, nicotine and methamphetamines. They found BCP prevented or reversed cellular behavioral changes resulting from drug exposure, again CB2 and PPAR receptors were the mechanism of action.

The new discoveries about terpenes increase our understanding of the ECS and show clearly the benefits of the entourage effects of full spectrum extractions. The more we learn about terpenes the more we realize that the natural world has much to offer us for our physical wellbeing.

Further Reading:

Younossi, Zobair M et al. “The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review.” Hepatology (Baltimore, Md.) vol. 77,4 (2023): 1335-1347. doi:10.1097/HEP.0000000000000004

Cheng, Yujie et al. “β-Caryophyllene ameliorates the Alzheimer-like phenotype in APP/PS1 Mice through CB2 receptor activation and the PPARγ pathway.” Pharmacology vol. 94,1-2 (2014): 1-12. doi:10.1159/000362689

Asth, Laila et al. “Effects of β -caryophyllene, A Dietary Cannabinoid, in Animal Models of Drug Addiction.” Current neuropharmacology vol. 21,2 (2023): 213-218. doi:10.2174/1570159X20666220927115811